Why Genomic Analysis Matters: P53

We now have the ability to analyze a patients genetics and assess the functioning of keys parts of their immune system involved in cancer development. Highly complex data systems analysis links gene mutations to epigenetic peer reviewed scientific studies that allow us to affect the function of gene and their products. This innovative development has wide spread potential in creating personalized medicine protocols for cancer patients and others with chronic illnesses.

I recommend all cancer patients to be assessed for mutations associated with innate immunity, and apoptosis using complex software such as OPUS23. There is a specific panel that I run, which is affordable and results in an invaluable report that can guide you nutritionally, with supplements, with conventional medications, and other factors.

In the next several blogs I will detail some of the genes related to innate immunity, and mutations I assess, why they are important and how we can affect them via personalized nutrition.

In order to bring some context to why certain genes are so important, we need to start at the beginning to where all cancer develops: within the cell cycle.

Most cells in our body undergo division process called mitosis. A cell grows, its DNA is exactly replicated in preparation for cellular division. What was once one cell becomes two and the process starts again. I've used two sentences to describe cell division, but in actuality it is anything that simplistic. There is a massive amount of control and check points involved because one mistake can cause a normal cells to be converted to a pre cancerous or cancer cell (aka immortal cells, aka undifferentiated cells). The cell cycle check points search for size, DNA replication, fidelity, nutrients, chromosome spindle attachment and DNA damage to name a few significant essential processed that must be executed correctly. If minor mistakes are made the cell does have the ability to correct them via repair enzymes or activation of a process called apoptosis (aka cell programmed death). Functioning of cell cycle surveillance for mistakes, repair enzymes, and apoptosis is vital to the prevention of cancer development.

All along the way nutrients from food and possibly supplements serve as coenzymes and cofactors to help this process run correctly. For example magnesium is essential in DNA replication fidelity, Vitamin B12 is necessary for DNA replication and antioxidants such as Vitamin C and E are necessary for chromosomal damage. Deficiencies in vitamins and minerals can cause an increase in cell cycle mistakes.

P53 is a gene that produces a protein known as the guardian of the genome. It is the most common gene mutation found in about 50% of all cancers. P53 is a type of tumor suppressor gen that encodes for a protein that inhibits the development and growth of tumors. The main function is to repair DNA in order to prevent altered DNA. When the DNA damage is too extensive to be repaired, P53 protein signals cells to undergo apoptosis.

Nutrients that act as agonists of P53 include lemons and also those in the mint family.

So how do you apply this information? For example, if you are a patient who has a significant (heterozygous) mutation in P53, you may want to use nutrients and supplements that act to increase its activity.

This innovation, especially being linked to scientific studies is a powerful tool.

Watch for write ups on other essential genes!

For more information on genomic analysis please contact Dr. Price at drlisapricend@gmail.com